Gynecology World Conference 2026

Abstract

BACKGROUND: The objective of this study was to evaluate and compare organ functions and metabolic profiles between patients with persistent hypertension after preeclampsia and those whose blood pressure normalized.

METHODS: This prospective cohort study included 84 patients with a history of pregnancy induced hypertension (PIH) and preeclampsia. At a follow-up visit 3.13 months postpartum, patients were evaluated for the persistence of hypertension and stratified into two groups: the hypertensive cohort (n = 25) and the normotensive control group (n = 59). Subsequently, organ function parameters and metabolic profiles were analyzed based on laboratory testing. Statistical analysis was performed using the Wilcoxon rank sum test for continuous variables and Fisher's exact test for categorical variables. A p-value of <0.05 was considered statistically significant.

RESULTS: Postpartum biochemical evaluation revealed significant disparities in hepatocellular and renal functions between the study groups. Specifically, patients with persistent hypertension exhibited markedly elevated liver enzyme profiles, as demonstrated by significantly higher median levels of alanine aminotransferase (ALT) [26 vs 15 IU/L, p<0.001] and aspartate aminotransferase (AST) [22 vs 16 IU/L, p<0.001] compared to their normotensive counterparts. Regarding glucose metabolism, a notable but non-significant mathematical shift occurred in the 1-hour post-load OGTT glucose level (154 vs 129 mg/dL, p=0.094), hinting at possible underlying insulin resistance. The lack of statistical significance across these metabolic and organ markers is likely due to the limited sample size of the hypertensive cohort, necessitating larger multi-center verification.

CONCLUSIONS: Persistent hypertension following preeclampsia is associated with altered postpartum biochemical and organ function profiles. These findings indicate that the resolution status of gestational hypertension may serve as an indicator of ongoing subclinical organ stress, highlighting the importance of continuous clinical monitoring in the postnatal period for this group of patients. Collecting further data is essential to validate these trends; therefore, active recruitment of new patients who meet the strict inclusion criteria is continuously ongoing.