Gynecology World Conference 2026

Abstract

Introduction: Endometriosis and migraines are two debilitating conditions that disproportionately affect women, often co-occurring and worsening each other’s symptoms. This review seeks to investigate the complex interplay between these two conditions, with a specific focus on the role of calcitonin gene-related peptide (CGRP) as a key mediator in their pathophysiology.

Methodology: A comprehensive search was conducted in PubMed and Google Scholar utilising specific search terms including “Endometriosis”, “Migraines”, “CGRP”, “CGRP AND Endometriosis”, “Migraine AND CGRP”, “Endometriosis AND migraine”. Inclusion criteria comprised reviews, original articles, observational studies, clinical trials, systematic reviews, and meta-analyses published within the last ten years (2016-2026). Non-relevant articles and those published over ten years ago were excluded.

Results: This review discusses that CGRP, a neuropeptide frequently associated with pain transmission and neuroinflammation, may initiate and worsen the pain experienced in both endometriosis and migraines. We also quote existing evidence that suggests that CGRP plays a significant role in central sensitization and chronic pain, particularly in relation to menstrual cycles, endometriosis, and migraines. Furthermore, the review discusses shared biological pathways, such as the dorsal root reflex and neuroinflammatory responses.

Conclusion: This review highlights the importance of CGRP as a potential therapeutic target for future pain management in migraine and endometriosis patients by quoting and discussing several studies in the past decade and identifies current gaps in literature.